Fluminant Hepatic Failure Treated by Plasma Exchange

Hepatic coma with renal failure, treated by repeated exchange transfusion.

Hepatic coma following acute hepatic necrosis carries a high mortality in spite of conventional therapy (Katz et al., 1962; McDonald and De la Harpe, 1963; Cook and Sherlock, 1965), but the concomitant development of renal failure makes the prognosis even worse (Hecker and Sherlock, 1956). Owing to the extraordinary capacity of the liver to regenerate, other forms of treatment have recently bee...

hepatic failure related to itraconazole use successfully treated by corticosteroids

Severe Leptospirosis with Multiple Organ Failure Successfully Treated by Plasma Exchange and High-Volume Hemofiltration

Background. Leptospirosis is a spirochetal zoonosis with complex clinical features including renal and liver failure. Case report. We report the case of a Swiss fisherman presenting with leptospirosis. After initial improvement, refractory septic shock and severe liver and kidney failure developed. The expected mortality was estimated at 90% with clinical scores. The patient underwent plasma ex...

Hepatic Failure Related to Itraconazole Use Successfully Treated by Corticosteroids

BACKGROUND Itraconazole is believed to carry a low risk of hepatic toxicity owing to its low affinity for the human P-450 enzyme. Therefore, hepatic failure caused by itraconazole is exceedingly rare. OBJECTIVES We report the case of a 46-year-old woman who developed hepatic failure related to itraconazole that was administered for the treatment of onychomycosis. Her condition deteriorated af...

Analysis of hepatic failure plasma by high performance gel-chromatography.

Plasma taken from hepatic failure rats induced by D-galactosamine was used to observe the variatiation in its chromatogram obtained by conducting a high performance gel-chromatography (TSK G2000SW used). The progress of hepatic failure caused distinct increase in the 12 abnormal peaks, especially peak b contained middle moelcular weight substances, which showed a good correlation with the condi...